Reflecting the critical threat posed by biological warfare and terrorism in a post 9-11 world, Medical Aspects of Biological Warfare addresses the weaponization of biological agents, categorizing potential agents as food, waterborne, or agricultural agents or toxins, and discusses their respective epidemiology. Recent advances in biomedical knowledge are presented that include descriptions of individual agents and the illnesses induced. Authors discuss biotoxins and explain methods for early identification for anthrax, plague, smallpox, alphaviruses, and staphylococcal enterotoxins. Case studies and research on successful management practices, treatments, and antidotes are also included. Contains updated and revised material since previous, 2007 edition.
Agency website: http://www.cs.amedd.army.mil/borden/
Contributors xi
Peer Reviewers xvii
Foreword by The Surgeon General xxi
Preface xxiii
1. Historical Overview: From Poisoned Darts to Pan-Hazard Preparedness 1
George W. Christopher, Daniel M. Gerstein, Edward M. Eitzen, and James W. Martin
2. Epidemiology of Biowarfare and Bioterrorism 37
Zygmunt F. Dembek, Julie A. Pavlin, Martina Siwek, and Mark G. Kortepeter
3. Food, Waterborne, and Agricultural Diseases 71
Zygmunt F. Dembek and Edwin L. Anderson
4. Consequence Management: The Local and National Response 93
Neal E. Woollen and Gary W. Carter
5. Medical Management of Potential Biological Casualties: A Stepwise Approach 109
Theodore J. Cieslak
6. Anthrax 129
Bret K. Purcell, Christopher K. Cote, Patricia L. Worsham, and Arthur M. Friedlander
7. Brucellosis 159
Bret K. Purcell, R. Martin Roop II, Arthur M. Friedlander, and David L. Hoover
8. Glanders 177
Susan L. Welkos, Bridget Carr Gregory, David M. Waag, and Mary N. Burtnick
9. Melioidosis 223
Paul J. Brett, David DeShazer, and Nicholas J. Vietri
10. Plague 247
Patricia L. Worsham, Thomas W. McGovern, Nicholas J. Vietri, Arthur M. Friedlander, and Joel Bozue
11. Tularemia 285
Matthew J. Hepburn, Todd M. Kijek, Wendy Sammons-Jackson, Arthur M. Friedlander, and
Zygmunt F. Dembek
12. Q Fever 305
Christina M. Farris and James E. Samuel
13. Multidrug-Resistant Bacterial Infections as a Threat to the US Military Health System: 321
Acinetobacter Infections as a Case Study Emil Lesho, Luther E. Lindler, Bruno Petruccelli, and Glenn Wortmann
14. Botulinum Toxin 337
Zygmunt F. Dembek, Leonard A. Smith, Frank J. Lebeda, and Janice M. Rusnak
15. Clostridium perfringens Epsilon Toxin 361
Bradley G. Stiles, Gillian Barth, and Michel R. Popoff
16. Ricin 373
Virginia I. Roxas-Duncan, Martha L. Hale, Jon M. Davis, John C. Gorbet, Patricia M. Legler, and Leonard A. Smith
17. Staphylococcal Enterotoxin B and Related Toxins Produced by Staphylococcus aureus and 403
Streptococcus pyogenes Kamal U. Saikh, Robert G. Ulrich, and Teresa Krakauer
18. Toxins from Venoms and Poisons 415
Scott A. Weinstein and Julian White
19. Marine Algal Toxins of Concern as Intentional Contaminants 461
Mark A. Poli and Mark R. Withers
20. Alphavirus Encephalitides 479
Shelley P. Honnold, Eric C. Mossel, Lesley C. Dupuy, Elaine M. Morazzani, Shannon S. Martin,
Mary Kate Hart, George V. Ludwig, Michael D. Parker, Jonathan F. Smith, Douglas S. Reed, and Pamela J. Glass
21. Hemorrhagic Fever-Causing Mammarenaviruses 517
Sheli R. Radoshitzky, Jens H. Kuhn, Peter B. Jahrling, and Sina Bavari
22. Henipaviruses 547
Arnold Park, Sheli R. Radoshitzky, Jens H. Kuhn, and Benhur Lee
23. Filoviruses 569
Sheli R. Radoshitzky, Sina Bavari, Peter B. Jahrling, and Jens H. Kuhn
24. Smallpox and Related Orthopoxviruses 615
Arthur J. Goff, Sara C. Johnston, Jason Kindrachuk, Kenny L. Lin, Peter B. Jahrling, John W. Huggins, M. Sofi Ibrahim, James V. Lawler, and James W. Martin
25. Emerging Infectious Diseases and Future Threats 645
Chris A. Whitehouse, Brett Beitzel, Zygmunt F. Dembek, and Alan L. Schmaljohn
26. Laboratory Identification of Threats 701
David A. Norwood, Timothy D. Minogue, Randal J. Schoepp, and Mark J. Wolcott
27. Medical Countermeasures 751
Phillip R. Pittman, Elizabeth S. Brown, and Matthew S. Chambers
28. Future Prospects of Vaccines and Antibodies in Biodefense 823
Jeffrey Froude II, Crystal W. Burke, and Jean-Nicolas Tournier
29. Aerobiology: History, Development, and Programs 855
Douglas S. Reed, Aysegul Nalca, and Chad J. Roy
30. Biosafety 869
David E. Harbourt, Catherine L. Wilhelmsen, Kristie M. Yeakle, and Robert J. Hawley
31. Biological Surety 895
Samuel S. Edwin, Virginia I. Roxas-Duncan, America M. Ceralde, Shelley C. Jorgensen, and Neal E. Woollen
32. Ethical Issues in the Development of Drugs and Vaccines for Biodefense 915
Arthur O. Anderson, Jeffrey E. Stephenson, and Bret K. Purcell
Abbreviations and Acronyms xxvii
Index
This book content will primarily appeal to military healthcare providers. Emergency first providers and responders, specialists in biological warfare and terrorism may also have an interest in this authoritative material.
